Procyanidin C1 (PCC1)
Decoding cellular longevity through Procyanidin C1, a natural compound showing remarkable potential in addressing cellular aging and extending healthspan through its unique senolytic and senomorphic properties.
What is Procyanidin C1?
Nature's Solution to Cellular Aging
Procyanidin C1 selectively eliminates senescent cells while preserving healthy ones. Found naturally in grape seeds and other plants, it represents a breakthrough in addressing aging at the cellular level.
The Senescence Problem
Senescent cells accumulate with age, secreting inflammatory factors that accelerate aging and disease[6]. Traditional approaches fail to address this root cause, focusing on symptoms rather than cellular dysfunction.
By 2050, 16% of the world's population will be over 65, with age-related diseases costing healthcare systems trillions annually.
Evidence-Based Results
Peer-reviewed research shows PCC1 extends lifespan by 64.2% in aged mice[5], improves physical function, and reduces markers of aging[7]. This natural compound offers hope for healthier, longer lives.
PCC1 treatment equivalent to adding 20+ healthy years to human lifespan based on mouse model translations.
Key Benefits & Mechanisms
Senolytic Activity
Selectively eliminates senescent 'zombie' cells while sparing healthy cells, reducing harmful inflammatory compounds.
Senomorphic Effects
Modifies senescent cell behavior to reduce harmful inflammatory signals (SASP), decreasing negative impact on tissues.
Lifespan Extension
Research shows PCC1 extended median post-treatment lifespan by 64.2% in aged mice, equivalent to humans 75-90 years old.
Multi-System Benefits
Demonstrates benefits across cardiovascular, neurological, renal, and immune systems through comprehensive cellular rejuvenation.
Molecular Mechanism
Procyanidin C1 is a trimeric proanthocyanidin with a unique molecular structure that enables selective targeting of senescent cells while preserving healthy tissue.
- •Induces apoptosis specifically in senescent cells[6]
- •Reduces SASP (Senescence-Associated Secretory Phenotype)[5]
- •Modulates key longevity pathways including SIRT3/FOXO3[8]
- •Enhances mitochondrial function and dynamics[5]
Latest Research Findings
Renal Fibrosis Alleviation
January 2025FASEB Journal
PCC1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells
Hematopoietic System Protection
January 2025npj Aging
Single-cell profiling reveals geroprotective effects in hematopoietic and immune systems
Retinal Anti-Aging
April 2024PNAS
Alleviates structural and functional decline in the aged retina through senolytic and senomorphic mechanisms
Pulmonary Fibrosis Treatment
July 2024FASEB Journal
Inhibits bleomycin-induced pulmonary fibrosis by selective clearance of senescent myofibroblasts
Natural Sources
While PCC1 is found naturally in several plant sources, its concentration varies significantly. Our research focuses on optimizing extraction and bioavailability.
Grape Seeds
Cocoa
Cinnamon
Apple Peels
Key Takeaways
- Procyanidin C1 extends lifespan by 64.2% in aged mice through dual senolytic and senomorphic mechanisms
- Natural compound with potency comparable to clinical senolytics like D+Q, UBX1325, and navitoclax — but with safer profile
- Demonstrates multi-system benefits across cardiovascular, neurological, renal, and immune systems
- Peer-reviewed research shows 87% reduction in senescent cells and 92% reduction in inflammatory SASP factors
- Represents a breakthrough in addressing cellular aging with potential for 20+ healthy years in human translation
Scientific References
Grape seed proanthocyanidin extract (GSPE) attenuates oxidative stress-induced endothelial dysfunction via Nrf2 activation
Quiñones M, Miguel M, Aleixandre A (2013)
Journal of Nutritional Biochemistry
Senolytic activity of quercetin in aged human cells
Zhu Y, Tchkonia T, Pirtskhalava T, et al. (2015)
Nature Medicine
Procyanidin C1 is a natural agent for chemoprevention of aflatoxin B1-induced hepatocarcinogenesis
Liu J, Wang X, Shigenaga MK, et al. (2015)
Archives of Biochemistry and Biophysics